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COMACC HOME > Training Programs >Cleveland State University
Cleveland State University
Affiliated Institutions: Cleveland Clinic Foundation,
MetroHealth Medical Center
Faculty and Research Interests
| Cleveland State
University: Department of Chemistry |
| David Anderson, PhD, DABCC |
HPLC and mass spectrometry of proteins,
proteomics |
| Mekki Beyachou, PhD |
Biosensors, bioelectrochemistry |
| Valentin Gogonea, PhD |
Computational chemistry, molecular
modeling of proteins and macromolecules |
| Baochuan Guo, PhD |
Mass spectrometry of proteins and DNA |
| Michael Kalafatis, PhD |
Biochemistry of blood coagulation and
thrombosis |
| Lily Ng, PhD |
FTIR, DNA, and proteins |
| John Turner II, PhD |
Biomedical imaging, spectroscopy |
| Robert Wei, PhD, DABCC |
Environmental pathology, free radicals |
| Yan Xu, PhD |
Capillary electrophoresis, immunoassays, and mass spectrometry
in bioanalysis |
| Aimin Zhou, PhD |
Advanced molecular biology techniques
for discovery of markers of cardiovascular and cancer diseases,
Rnase biochemistry |
| Cleveland Clinic Foundation: Department
of Clinical Pathology |
| Manjula K. Gupta, PhD |
Endocrine aspects of prostate and breast
cancer, RT-PCR detection of circulating tumor cells, autoimmune
endocrine disorders |
| Frederick Van Lente, PhD, DABCC |
Cytokines, metabolism of selenium |
| Cleveland Clinic
Foundation: Lerner Research Institute |
| Alexandru Almasan, PhD |
Cell cycle control, radiation biology,
lung cancer |
| Sipra Banerjee, PhD |
Role of DNA repair genes in initiation
and progression of cancer |
| Charles Bevins, MD, PhD |
Antimicrobial peptides in innate host
defense of mammalian epithelial mucosa |
| Graham Casey, PhD |
Tumor suppression, cancer predisposition,
breast/ovarian cancer |
| Martha Cathcart, PhD |
Human monocyte activation, respiratory
burst activation, lipid oxidation, signal transduction, lipoprotein
oxidation |
| Guy Chisolm, III, PhD |
Lipoprotein oxidation, lipoprotein-cell
interactions, lipoprotein transport into tissue |
| John Crabb, PhD |
Proteomics, biochemistry of vision and
retinal degenerative diseases |
| Paul DiCorleto, PhD |
Regulation of endothelial cell gene expression
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| Joseph DiDonato, PhD |
Proinflammatory cytokine signal transduction
chronic inflammatory diseases |
| Donna Driscoll, PhD |
Post-transcriptional regulation of gene
expression, RNA structure and function |
| Serpil Erzurum, MD |
Oxidant regulation of gene expression,
mechanisms of airway inflammation, asthma, gene therapy |
| Paul Fox, PhD |
Endothelial cell motility, cellular oxidation
processes, ceruloplasmin |
| Ram Ganapathi, PhD |
Molecular pharmacology of antitumor drug
resistance |
| Stanley Hazen, MD, PhD |
Leukocyte peroxidases; free radicals
and reactive oxygen species; oxidative damage of biomolecules in
disease |
| Mie-Jae Im, PhD |
Hormone signal transduction, GTP-binding
protein, transglutaminase |
| Donald Jacobsen, PhD |
Homocysteine: vascular biochemistry,
metabolism and role in atherogenesis |
| Andrew Larner, PhD |
Signaling pathways regulating biological
actions of interferons and other cytokines |
| Xiaoxia Li, PhD |
Molecular mechanisms of inflammatory cytokine
signal transduction and regulation of innate immunity; regulation
of NFKB activation. |
| Alan Marmorstein, PhD |
Etiology and mechanisms of age-related macular
degeneration |
| Kunio Misono, PhD |
Protein structure and function; receptor
signal transduction; protein analytical chemistry, bio-conjugate chemistry,
and peptide chemistry |
| Richard Morton, PhD |
Lipid and lipoprotein metabolism, membrane
structure-function relationships, lipid-protein interactions |
| Richard Padgett, PhD |
Mechanisms of RNA splicing in vivo and in
vitro |
| Edward Plow, PhD |
Molecular mechanisms of cell adhesion and
migration |
| Jun Qin, PhD |
Biomolecular NMR spectroscopy, protein-protein
and protein-nucleic acid interactions, signal transduction |
| Robert Silverman, PhD |
RNA stability, interferons, antivirals, antisense,
apoptosis |
| George Stark, PhD |
Amplification, interferons, signal transduction,
transcription |
| Dennis Stuehr, PhD |
Structure and biochemistry of nitric oxide
synthases |
| Thomas Wiembs, PhD |
Membrane traffic in epithelial cells, SNARE
membrane fusion machinery, renal cell carcinoma, polycystic kidney
disease |
| Bruce Trapp, PhD |
Cellular and molecular biology of myelination,
demyelination, and dysmyelination |
| Bryan Williams, PhD |
Molecular mechanisms of control of cellular
proliferation and resistance to disease |
| Yan Xu, PhD |
Molecular mechanisms of the development of
ovarian cancer |
| Vivien Yee, PhD |
X-ray crystallography, protein structure-function,
transglutaminases, blood coagulation |
| MetroHealth Medical Center: Department
of Pathology |
| Michael Ip, PhD, DABCC |
Troponin I and myoglobin in cardiac diagnosis,
GGT and AFP variants in the diagnosis of hepatocellular carcinoma |
Program Listing:
| Levels of training:
Number of positions available per year:
Duration of program:
Approximate annual salary or stipend:
Source of funding:
Current number of trainees:
Number of past graduates (over last 7 years): |
MS, PhD
Varies
2 years for MS, 5 years for PhD
$15,000-16,000
Teaching and research assistantships
10
9 PhDs |
Application Procedures:
| Prerequisites: |
BS in chemistry, GRE, TOEFL (if degree
is from an institution outside of the United States), and two letters
of recommendation. |
| Procedures: |
Inquire |
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Program Description:
The graduate program in Clinical Chemistry is a
dynamically integrated program merging the fields of biomedicine,
clinical diagnosis, and analytical chemistry. The program is jointly
administered by Cleveland State University and The Cleveland Clinic
Foundation, in affiliation with MetroHealth Medical Center. In addition,
The Veterans Affairs medical center actively participates. The Clinical
Chemistry program gives rigorous instruction in all aspects of disease
processes, with in-depth coverage given for testing strategies and
methodologies used in disease diagnosis. PhD graduates are trained
as directors of clinical laboratories (in hospitals, medical centers,
and reference laboratories) and as research scientists in the in-vitro
diagnostics and biotechnology industries. MS graduates are trained
for positions in industry.
MS and PhD Clinical Chemistry students take one year of clinical
chemistry (two 4-semester-redit courses), one year of advanced biochemistry
(two 4-semester-credit courses), one course in biotechnology techniques
(4 semester credits), one chemistry elective course (3 semester
credits), two seminar courses (1 semester credit each) and a summer
internship course in the clinical laboratory (11 semester credits).
In addition, PhD students take four courses of special topics in
clinical chemistry (1 semester credit each), four courses of clinical
chemistry seminar (1 semester credit each—includes case histories,
clinical pathology conferences, and student presentations) and an
optional second summer internship in the clinical laboratory (11
semester credits). Each internship course encompasses an 8 week
rotation in a medical center clinical laboratory, where the student
learns the principles and practice of clinical laboratory testing.
The student may also work on developmental projects in the internship
courses. The second summer internship course gives experience in
specialized clinical laboratory techniques.
Dissertation research is an important component of the Clinical
Chemistry PhD degree. PhD students begin earnest work on their dissertation
research at the start of their second year. Students do research
at state-of-the-art facilities at Cleveland State University, The
Cleveland Clinic Foundation, and other medical centers. The program
includes over 40 faculty members who collectively have a broad range
of research interests in the fields of disease mechanisms and diagnosis,
bioanalytical chemistry, biomedicine, and molecular biology. Cutting-edge
bioanalytical technologies used in research include mass spectrometry
(including MALDI-TOF, ESI-MS-MS, ESI-ion trap, HPLC, conventional
and capillary electrophoresis, immunoassays, ultracentrifugation,
NMR, EPR, FTIR, absorption spectrophotometry, spectrofluorometry,
x-ray crystallography, molecular biology techniques, computational
chemistry, biosensors, etc.
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